Preparing high-quality lamellae is essential for achieving meaningful cryo-ET data. Tescan cryo-solutions support all preparation strategies, including on-grid milling, waffle-method, and cryo lift-out, thereby providing researchers with the flexibility to work with diverse sample types, ranging from isolated cells to tissues and model organisms. Integrated cryo-stages and contamination-free transfer systems ensure reliable, artifact-free thinning of vitrified specimens, maintaining structural integrity and native hydration throughout the workflow.
Capture molecular-level detail while preserving the near-native state of your sample
Cryo-electron microscopy (cryo-EM) has revolutionized structural biology. By enabling the observation of cellular structures in their near-native state at molecular resolution, this groundbreaking technology is reshaping how scientists understand life at the nanoscale. Whether preparing thin lamellae for Cryo-Electron Tomography (Cryo-ET) to obtain the finest structural details or performing Cryogenic volume imaging, Tescan workflows ensure precision, reliability, and sample integrity throughout the entire process.
FOR CRYO ELECTRON MICROSCOPY
Cryo-ET sample preparation
Cryo volume imaging
Cryo volume imaging bridges the gap between molecular and cellular scales, enabling visualization of complex biological environments in three dimensions while preserving the sample’s native ultrastructure. The sample is serially milled with a focused ion beam, imaging each newly exposed surface to generate a detailed 3D reconstruction. This approach provides nanometer-scale resolution across entire volumes.
for EVERYDAY ELECTRON MICROSCOPY WORKFLOW
Tescan SOLARIS X2
Tescan SOLARIS X2 combines MISTRAL™ Xe plasma FIB with UHR-SEM immersion optics for precise lamella preparation and high-quality cryo imaging. Its enhanced beam profile enables fast milling and low-energy polishing, ideal for large-volume and high-throughput cryo workflows.
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MISTRAL™ Xe Plasma FIB Column: Enhanced beam profile for fast milling and precise low-energy polishing.
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UHR-SEM Immersion Optics: Optimized for high-quality cryo imaging.
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Built-in Tescan Cryo-Nanomanipulator: Temperature-controlled system for safe and efficient lamella lift-out
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Integrated CLEM: Precise ROI targeting with integrated METEOR 2.0
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Tescan Essence™ Software: Designed for multi-user environments, ensuring effortless operation regardless of experience level.
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Integrated Leica/Quorum cryo workflow
The SOLARIS X2 offers both cryo-stable performance and intuitive navigation, ensuring consistent and reproducible results, even in the most demanding applications.
Tescan AMBER X2
High-performance plasma FIB-SEM system designed for demanding cryo and room temperature structural analysis.
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3D FIB-SEM tomography of large volumes and/or hard materials such as shells, bones, and dental tissue
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Superior quality cryo lamella preparation with MISTRAL™ Plasma FIB for fast rough milling and precise low-energy polishing
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Integrated CLEM: Precise ROI targeting with integrated METEOR 2.0
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Built-in Tescan Cryo-Nanomanipulator: Temperature-controlled system for safe and efficient cryo lift-out
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Integrated Leica/Quorum cryo workflow
The Tescan AMBER X2 uses plasma FIB milling to enable high-throughput structural analysis under ambient and cryogenic conditions, offering speed and efficiency. It delivers reliable, artefact-free results for advanced life science research, from large-volume 3D tomography of hard biological materials to high-quality cryo lamella preparation.
Tescan AMBER 2
Flexible and robust solution designed to meet the complex requirements of modern research centers.
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UHR BrightBeam™ optics deliver high-contrast imaging of non-conductive and beam-sensitive samples at very low kV.
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FIB-SEM tomography: Ultra-high resolution 3D reconstructions of cells and cellular structures
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Seamless switching between ambient and cryogenic modes
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Optimized cryo-TEM lamella workflow
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Integrated Leica/Quorum cryo workflow
Tescan AMBER 2 provides life scientists with a comprehensive platform for both cryogenic and ambient applications. From UHR imaging of beam-sensitive samples to fully integrated correlative cryo workflows, it preserves biological integrity while delivering high-resolution insights into tissues, and subcellular architectures.
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